Effects of Tongxinluo Ultramicro-pulverization on acute myocardial infarction in anaesthetic dogs

Abstract

Abstract: AIM: To study the effects of Tongxinluo Ultramicro-pulverization(TXLU) on acute myocardial infarction in anaesthetic dogs. METHODS: The acute myocardial infarction model was made by ligation of left anterior descending (LAD) artery.The experiments adopted the epicardial electrogram to measure the scope and degree of myocardial ischemia, the quantitative histologic assay (triphenytetrazolium chloride, TTC stain) to determine the size of myocardial infarction. The blood oxygen pressure and oxygen saturation were measured by blood-gas analyzer.The utilization rate of myocardial oxygen was calculated. RESULTS: Compared with the controls and before dosing, the TXLU obviously alleviated the degree of myocardial ischemia (Σ-ST) and narrowed the ischemic area indicated by the epicardium electrograph data display and TTC staining.In addition, TXLU could decrease the utilization rate of myocardial oxygen. CONCLUSION: TXLU could attenuate the damage subjected to myocardial ischemia and infarction, restore the utilization ratio of myocardial oxygen.

Key words: Tongxinluo Ultramicro-pulverization, myocardial infarction, infarct size, epicardial electrogram

CLC Number:

R965.1

ZHU Hui-ming, TANG Si-wen, ZHANG Hui-xin, WANG Hong-tao, ZHAO Shao-hua, WU Yi-ling. Effects of Tongxinluo Ultramicro-pulverization on acute myocardial infarction in anaesthetic dogs[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(3): 328-331.

References

[1] 刘建勋, 尚晓泓, 王刚, 等.通心络胶囊对实验性心肌缺血、心律失常及实验性高脂血症的影响[J].中国中西医结合杂志, 1997, 17(7):425-428.
[2] 曾定尹, 关启刚, 孙喜琢, 等.通心络抑制IL-1β 介导的小型家猪冠状动脉痉挛的作用及机制[G].络病学基础与临床研究(2) ——— 首届国际络病学大会论文集, 2005.
[3] 肖文良, 戴华, 姜志安, 等.通心络胶囊对不稳定型心绞痛患者内皮细胞保护作用的研究[J].中华心血管病杂志, 2002,30(5):268.
[4] 张艳慧, 吉梅, 张艳玲, 等.通心络胶囊对血脂异常患者内皮功能影响的临床研究[J].疑难病杂志, 2005,4(2):92-93.
[5] 彭世志, 蒋兰林, 庞秋辉.通心络胶囊对冠心病患者血管内皮功能及血脂的影响[J].右江民族医学院学报, 2006, 28(4):540-541.
[6] 石正洪, 董为伟, 朱晓红.通心络对脑缺血再灌注氧化损伤作用的实验研究[J].中华神经科杂志, 2003,36(4):260.
[7] 徐叔云, 卞如濂, 陈修.药理实验方法学[M].3 版.北京:人民卫生出版社, 2002:1042-1059.
[8] 袁丽萍, 范丽, 董六一, 等.山茶花总黄酮TFC 对实验性心肌缺血的保护作用[J].中药新药与临床药理, 2004, 15(1):252-281.
[9] Yang H, Wu WK, Chen JP.Effect of Baoxin capsule on hemodynamic in dogs with myocardial ischemia[J].Chin J Pathophysiol, 2000, 16(3):218-221.
[10] Ma SP, Wang ZR, Chen XF.Effect of QDTMT on left ventricular in dogs with acute myocardial ischemia[J].J Fourth Mil Med Uinv, 2000, 21(6):S110-S112.
[11] 文洪林, 尚菊菊, 刘红旭, 等.通心络对垂体后叶素诱发大鼠急性心肌缺血影响的血清学研究[J].北京中医药大学学报:中医临床版, 2006, 13(2):5-6.
[12] 杨跃进, 赵京林, 孟亮, 等.中药通心络(超微粉碎) 对猪急性心肌梗死再灌注后无再流的影响[J].中国中西医结合杂志, 2006, 26(1):49-53.

[1]	HAO Xiao, ZHAO Mei, WANG Wenjing, ZHANG Feifei, LIU Huiliang, DANG Yi, LI Shuren, QI Xiaoyong. Application of sodium-glucose cotransporter 2 inhibitors in acute myocardial infarction [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(7): 824-831.
[2]	QIAN Jin, WANG Fengyan. Influence factors of serum NT-proBNP level in elderly patients with acute myocardial infarction after PCI and its influence on short-term prognosis [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(6): 658-665.
[3]	ZENG Xiaofan, XU Yiqi, LIU Shu, WU Qian, LI Zibao, HE Junjun, JIN Yuelong, ZHAO Yongli, HE Chunling, GAO Jialin. Retrospectively analysis of the effect of low-dose aspirin on primary prevention of non-fatal myocardial infarction and cerebral infarction in patients with type 2 diabetes mellitus [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(6): 665-671.
[4]	CHEN Xi, LI Yongjun. Effects of Chinese patent medicine for activating blood circulation on cardiac repair after myocardial infarction [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(6): 680-688.
[5]	YANG Yongkang, LI Jing, RAO Tingcai, ZHANG Junyan. Hyperoside ameliorates the injury of heart and thoracic aorta in mice with myocardial infarction by regulating autophagy pathway [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2021, 26(6): 601-608.
[6]	ZHAO Wei, WU Youyang, LIN Cong, HUANG Shiwei, CHEN Hao, JIANG Wenbing. Effects of pterostilbene on myocardial function, myocardial fibrosis and inflammatory response in rats with acute myocardial infarction and on Notch1/eIF3a signaling pathway [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(5): 498-504.
[7]	FU Xiaomei, HUO Ran, DENG Sai, LIN Chaojin, FAN Jinghao, WANG Ping, LI Songpei, QIN Aiping, ZOU Minghui, YU Xiyong. Exosomes derived from LPS-stimulated bone marrow mesenchymal stem cell improve myocardial inflammation and fibrosis after myocardial infarction in mice [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(8): 841-851.
[8]	PU Chun, TAO Qingsong, ZHU Xiang, QIN Mingming, WU Qiwen, FENG Gang. Value of three cardiac markers in the early diagnosis of acute myocardial infarction [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(1): 82-86.
[9]	WEI You-quan, CAO Heng. Effects of recombinant human insulin-like growth factor-Ι on the expression of matrix metalloproteinases and interstitial degradation of myocardial infarction rats [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(8): 866-871.
[10]	ZHAO Chun-mei, WANG An-cai, WANG De-guo. Progress on the treatment of cardiovascular disease with bone marrow stem cells [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(8): 948-952.
[11]	LI Yi-min, HUANG Jin, LU Zhi-ping, LI Xiang-yu, HE Sheng-hu. Effects of tirofiban on the level of platelet microparticles(PMPs) in patients with acute ST-segment elevation myocardial infarction undergoing emergency interventional treatment [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(12): 1403-1406.
[12]	ZHOU Yong, HUANG Song-qun, XU Fei. Efficacy on slow bleeding and safety of using tirofiban before and during emergency PCI in patients with acute ST-segment elevation myocardial infarction [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(11): 1268-1271.
[13]	ZHU Lin-lin, XIE Xiang-rong, ZHANG Juan, SHAN Shou-jie , CHEN Shao-liang. Long-term efficacy of intracoronary stem cells transplantation in patients with acute myocardial infarction [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(6): 674-679.
[14]	LI Shu, ZHANG Gen-bao, HONG Yun, LU Xiao-hua. Study on mechanisms of Agkistrodon halyx pallas venom PCA to improve heart function in rats with acute myocardial infarction [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(2): 141-146.
[15]	ZHU Gang-yan, XU Hong-xin, TIAN Yi-hao, MA Hong-mei, TANG Shi-qi, WANG Fu-liang, WU Song-lin. Ameliorative effects of trimetazidine on bone marrow mesenchymal stem cells viability through Bcl-2 expression [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(7): 729-735.