Abstract: AIM: To observe the clinical effect of combination therapy with ozagrel and low molecular weight heparin on progressive cerebral infarction. METHODS: 96 cases with acute progressive cerebral infarction were randomly divided into treatment group (48 cases) and control group (48 cases).The control group was only administered with 80 mg sodium ozagrel, bid, for 14 days.And the treatment group was administered with 80 mg sodium ozagrel, bid, for 14 days and 0.4 mL low molecular weight heparin sodium injection, bid, for 14 days.The number of platelet, blood clotting routine and the severity of neuro-functional defect (NDS) of both groups were detected before and after 14 days treatmeat. RESULTS: After 14 days treatment, the NDS of treatment group was significantly lower than that of control group (P <0.05). The efficacy of treatment group was significantly better than that of control group (P <0.05).Both the number of platelet and the blood coagulation time were in normal range. CONCLUSION: Sodium ozagrel combined with low molecular weight heparin sodium are an effective and safe therapy for progressive cerebral infarction.

Key words: sodium ozagrel, low molecular weight heparin, cerebral infarction, efficacy