Abstract: AIM: To investigate the effect of postoperative analgesia with Lornoxicam and butorphano after laparoscopic cholecystectomy (LC). METHODS: 90 ASA Ⅰ-Ⅱpatients scheduled for LC were randomly divided into three groups:group lornoxicam (n = 30) received lornoxicam 8 mg, group butorphano (n = 30) received butorphano 1mg, group NS (n =30) received 0.9%NS 2 mL at the time of the complaint of pain by the patients after extubate of tracheal catheter. Postoperative abdomen pain was assessed by visual analog scale (VAS), the patients were assessed by brungmann comfort scale (BCS) and Ramesay score (RS) within 1, 6, 12, 24 hours postoperatively.Side-effects were also assessed. RESULTS: The patients of group lornoxicam and butorphano had significantly higher BCS and RS scores than group NS (P <0.01), both of them also had significantly lower VAS than group NS (P <0.01).Group lornoxicam caused no more sideeffect, such as nausea, vomiting than group butorphano and NS(P <0.05). CONCLUSION: The study suggests that postoperative analgesia with lornoxicam 8 mg or butorphano 1 mg provide satisfactory postoperative pain relief with no more side-effects for patients undergoing LC.

Key words: lornoxicam, butorphano, postoperative analgesia, laparoscopic cholecystectomy