Effects of natural drugs on CYP3A

Abstract

Abstract: Natural drugs are widely used in China and Southeast Asia, and they are more and more popular in Europe and America.Though complicated their component are, their monomer and active ingredients are metabolized by CYP450s as synthetic drugs. CYP3A is one of the most important cytochrome P450, and more than half of drugs are metabolized by this enzyme.Now many in vitro and in vivo researches indicate that many natural drugs and the ingredients effect CYP3A widely, and lead to drug-drug interactions in combined use.So researching on the regulation of natural drugs will not only benefit medication safety, but also make sense to the development of new drugs and revealing the mechanism of drug-drug interactions.

Key words: natural drugs, CYP3A, inhibitory action, induction

CLC Number:

R968

YI Fei, ZHOU Hong-hao. Effects of natural drugs on CYP3A[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(3): 344-349.

References

[1] 张荣, 朱大岭.CYP3A 基因表达分子机制的研究进展[J].医学研究通讯, 2005,34(2):57-59.
[2] 唐跃年, 陈颖.P450 3A 亚型的测定[J].上海交通大学学报:医学版, 2004, 24(10):874-875.
[3] 朱冰, 周宏灏.CYP3A 的分子机制研究进展[J].中国药理学通报, 2000, 16(6):614-617.
[4] Tummel KE, Wilkinson GR.In vitro and in vivo drug interactions involving human CYP3A[J].Annu Rev Pharmacol Toxical, 1998,38(1):389-430.
[5] 吕水利, 黄英.药物代谢中的CYP3A 基因[J].国外医学药学分册, 2001, 28(5):307-308.
[6] Scott R.Inhibition of human cytochrome P450 enzymes by constituents of St.John's Wort, an herbal preparation used in the treatment of depression[J].J Pharm Exp Ther, 2000, 294(1):88-96.
[7] Moore L, Goodwin B, Johns S, et al.St.John's Wort induced hepatic drug metabolism through activation of the pregnane X receptor[J].Proc Natl Acad Sci, 2000, 97(13):7500-7502.
[8] 孙剑寒, 郑一凡, 祝慧娟, 等.染料木黄酮、拟雌内酯及槲皮素对孕烷X 受体介导的CYP3A4 转录的调节作用[J].中国药理学与毒理学杂志, 2004, 18(3): 219-223.
[9] 张芳芳, 郑一凡, 祝慧娟, 等.山奈酚和槲皮素对大鼠细胞色素P450 酶活性的影响[J].浙江大学学报:医学版, 2006,35(1):18-22.
[10] Zhou JQ, Tang ZQ.Effect of quercetin on CYP1A2, CYP2E1, CYP3A2 activities and its inhibitory mechanism studies in rat liver microsomes[J].J Chin Pham Sci, 2005, 14(4):231-236.
[11] Guerra MC, Speroni E, Broccoli M, et al.Comparison between Chinese medical herb Pueraria lobata crude extract and its main isoflavone puerarin antioxidant properties and effect on rat liver CYP-cataly sed drug metabolism[J]. Life Sci, 2000, 67(24):2997-3006.
[12] Venkataramanan R, Ramachandran V, Komoroski BJ, et al.Milk thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures[J].Drug Metab Dispos, 2000, 28(11):1270-1273.
[13] Zuber R, Modriansky M, Dvorak Z, et al.Effect of silybin and its congeners on human liver microsomal cytochrome P450 activities[J].Phytother Res, 2002, 16(7): 632-638.
[14] Foster BC, Vandenhoek S, Hana J, et al.In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products[J].Phytomedicine, 2003, 10(4):334-342.
[15] Guo LQ, Taniguchi M, Xiao YQ, et al.Inhibitory effect of natural furanocoumarins on human microsomal cytochrome P450 3A activity[J].Jpn J Pharmacol, 2000, 82(2):122-129.
[16] Guo LQ, Taniguchi M, Chen QY, et al.Inhibitory potential of herbal medicines on huamn cytochrome P450-mediated oxidation:properties of umbelliferous or citrus crude drugs and their relative prescriptions[J].Jpn J Pharmacol, 2001, 85(4):399-408.
[17] Liu Y, Li W, Li P, et al.The inhibitory effect of intestinal bacterial metabolite of ginsenosides on CYP3A activity[J].Biol Pharm Bull, 2004, 27(10):1555-1560.
[18] 古赛, 姜蓉.枸杞多糖对酒精性脂肪肝大鼠肝细胞色素P4503A 的影响[J].重庆医科大学学报, 2007,32(4):371-375.
[19] Iwata H, Tezuka Y, Kadota S, et al.Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract[J].Drug Metab Dispos, 2004,32(12):1351-1358.
[20] Wang X, Zhao X, Li D, et al.Effects of ganoderma lucidum polysaccharide on CYP2E1, CYP1A2 and CYP3A activities in BCG-immune hepatic injury in rats[J].Biol Pharm Bull, 2007,30(9):1702-1706.
[21] 吴笑春, 辛华雯, 朱敏.盐酸小檗碱与环孢素A 合用对小鼠肝P450 同工酶的影响[J].中国药学杂志, 2002,37(7):496-499.
[22] 李罄, 吴笑春, 辛华雯, 等.盐酸黄连素对肾移植受者环孢素A 增效作用的临床药代动力学研究[J]. 中国临床药理学杂志, 2001, 17(6):448-450.
[23] 代方国, 罗仁, 王宇光, 等.甘遂配伍甘草对大鼠肝脏CYP3A2 影响[J].第四军医大学学报, 2005, 26(10):951-953.
[24] 杨静, 彭仁, 于皆平.18 α-甘草酸下调“ 胶原蛋白凝胶三明治” 培养的大鼠肝细胞P450 酶活性及mRNA 表达[J].中国药理学与毒理学杂志, 2001, 15(2):155-158.
[25] 杨静, 彭仁, 孔锐, 等.18α-甘草酸二铵对大鼠肝脏细胞色素P450 和II 相酶的影响[J].药学学报, 2001,36(5):321-324.
[26] Kan JJ, Wang HW, Liu TY, et al.Modulation of cytochrome P2450-dependent monooxygenases, glutathione and glutathione S-transferase in rat liver by genposide from Gardenia jasminoldes[J].Food Chem Toxicol, 1997,35(10 11):957-965.
[27] Markowitz JS, Donovan JL, DeVane CL, et al.Effects of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme[J].JAMA, 2003, 290(11): 1500-1504.
[28] Gödtel-Armbrust U, Metzger A, Kroll U, et al.Variability in PXR-mediated induction of CYP3A4 by commercial preparations and dry extracts of St John's wort[J].Naunyn Schmiedebergs Arch Pharmacol, 2007,375(6):377-382.
[29] Mu Y, Zhang J, Zhang S, et al.Traditional Chinese medicinesWu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Gly cyrrhiza uralensis Fisch)activate pregnane X receptor and increase warfarin clearance in rats[J].J Pharmacol Exp Ther, 2006,316(3):1369-1377.
[30] Paolini M, Pozzetti L, Sapone A, et al.Effect of licorice and glycyrrhizin on murine liver CYP-dependent monooxygenases[J].Life Sci, 1998, 62(6):571-582.
[31] 刘晓磊, 唐靖, 宋娟, 等.川芎嗪对大鼠灌服环孢素A 药代动力学的影响[J].药学学报, 2006, 41(9):882-887.
[32] Hsiu SL, Hou YC, Wang YH, et al.Quercetin significantly decreased cyclosporin oral bioavailability in pigs and rats[J].Life Sci, 2002, 72(3):227-235.
[33] Komoroski BJ, Parise RA, EgorinMJ, et al.Effect of the St.John's wort constituent hyperforin on docetaxel metabolism by human hepatocyte cultures[J].Clin Cancer Res, 2005, 11(19):6972-6979.
[34] Smith PF, Bullock JM, Booker BM, et al.Induction of imatinib metabolism by hypericum perforatum[J].Blood, 2004, 104(4):1229-1230.