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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2008, Vol. 13 ›› Issue (5): 545-551.

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Simulation and prediction of in vivo drug metabolism in human population based on in vitro-in vivo extrapolations

WANG Yin1,2, YANG Jin1, FU Ji-hua2, LIU Xiao-dong1, WANG Guang-ji1   

  1. 1Key Laboratory of Drug Metabolism and Pharmacokinetics, 2Department of Physiology, China Pharmaceutical University, Nanjing 210009, Jiangsu, China
  • Received:2007-12-21 Revised:2008-02-26 Published:2020-11-09

Abstract: The major failure of new drug has been blamed on deficiencies in in vivo studies of drug efficacy and safety. It will improve the efficient of drug screen, if predicting in vivo pharmacokinetic parameters through in vitro-in vivo extrapolations (IVIVE), before the clinical trails. In this review, the significance, calculation, and application of in vivo drug clearance through Simcyp, a predictive software based on PBPK model, will be reviewed. Finally, some perspective of Simcyp were discussed.

Key words: Simcyp, PBPK model, in vitro-in vivo extrapolation, clearance

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