Progress and research in pharmacogenetics of OATP1B1

Abstract

Abstract: Many types of drug transporters are expressed in different organs.The transporters play important roles in drug absorption, distribution and excretion, and lead to consequences for interindividual differences in disposition kinetics, interaction profiles of clinical drugs, susceptibility to side effects and treatment efficacy.The genetic polymorphisms have been shown to alter both the expression and function of their gene products.The identification of allelic variations and their functional confirmations is a necessary step towards the use of genetic information for personalized medicine.This review focuses on the role of organic anion transporting polypeptide 1B1 (OATP1B1) gene polymorphisms in pharmacokinetic and pharmacodynamic consequences in pharmacotherapy.

Key words: OATP1B1, polymorphism, transport, pharmacokinetics, drug efficacy

CLC Number:

R969

ZHANG Wei, HE Yi-jing, ZHOU Hong-hao. Progress and research in pharmacogenetics of OATP1B1[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(7): 721-729.

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