Tissue distribution of triptolide in rats

Abstract

Abstract: AIM: To establish an HPLC method for the analysis of tissue distribution of triptolide in rats.METHODS: The concentrations of triptolide in biological samples were determined by an HPLC method with UV detection.RESULTS: The results of tissue distribution showed that triptolide was distributed widely in rats.The highest levels were found in lung, liver and kidney after i.v.administration (200 μg/kg) of triptolide.The peak levels appeared at 5 min and decreased significantly in 60 min in most tissues. CONCLUSION: Triptolide is widely distributed and rapidly eliminated in main tissues, and it can permeate blood brain barrier and blood testicle barrier.

Key words: triptolide, HPLC, tissue distribution

CLC Number:

R969.1
R285

HUANG Xiu-wang, XU Jian-hua, CHEN Yuan-zhong. Tissue distribution of triptolide in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(7): 764-767.

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Tissue distribution of triptolide in rats

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