Abstract: AIM:To observe the clinical effect of Quyuningxin pill on the serum concentration of C-reactive protein (CRP) from coronary heart disease (CHD) patients with unstable angina pectoris, and explore the related mechanisms. METHODS:Sixty patients of CHD with unstable angina pectoris were divided randomly into treatment group (30 cases) and control group (30 cases). The treatment group was given conventional western medical combined with Quyuningxin pill. The control group was given conventional western medical only. The course of treatment lasted for four weeks.The serum CRP concentration was measured before and after treatment. The changes of angina pectoris and other clinical syndrome as well as electrocardiogram were also observed. RESULTS:The serum concentration of CRP of Quyuningxin pill treated group was decreased markedly comparing with that of control group (3. 8 ±0. 9 vs 5. 8 ±1. 8, P <0. 05). After the treatment, the total effective rate of angina pectoris remission, clinical syndrome, electrocardiogram in treatment group were significantly higher than those in the control group (89. 29%, 89. 29%, 75. 0% vs 66. 67%, 66. 67%, 55. 56% P <0. 05). CONCLUSION: Quyuningxin pill can significantly improve myocardial ischemia related symptoms together with the serum CRP concentration in the patients with unstable angina pectoris.

Key words: Quyuningxin pill, unstable angina pectoris, Zhuoyuhujie syndromes, C-reative protein