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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2009, Vol. 14 ›› Issue (8): 928-932.

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A Controlled study on ibuprofen pseudoephedrine hydrochloride and chlorpheniramine Maleate tablets and paracetamol pseudoephedrine hydrochloride and chlorphenamine maleate tablets in the treatment of upper respiratory tract infection

XUE Cheng1, JIANG Jing-han1, WANG Wei-hua1, ZHANG Jian-chu2, XIONG Sheng-dao3, ZHANGWei4, LIU Chun5   

  1. 1Department of Emergency Internal Medicine , Yijishan Hospital of Wannan Medical College , Wuhu241000 , Anhui ,China;
    2Breath Internal Medicine , Affiliated Union Hospital of Tongji Medical College , Huazhong University of Sci-ence and Technology , Wuhan 430033 , Hubei , China;
    3Breath Internal Medicine , Affiliated Tongji Hospital of Tongji Medical College , Huazhong University of Science and Technology , Wuhan430033 , Hubei , China;
    4Breath Internal Medicine , the First Affiliated Hospital of Nanchang University , Nanchang 430000 , Jiangxi , China;
    5Breath Internal Medicine , the Third Xiangya Hospital of Central South University , Changsha 410000 , Hunan , China
  • Received:2008-11-19 Revised:2009-05-27 Online:2009-08-26 Published:2020-10-30

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Abstract: AIM: To evaluate the efficacy and safety of ibuprofen pseudoephedrine hydrochloride and chlorpheniramine Maleate tablets for the treatment of upper respiratory tract infection. METHODS: A multi-center,double-blind, randomizde controlled and positive drug parallel trial was conducted.226 patients were enrolled and divided into two groups.Group A (112 cases)were treated with ibuprofen pseudoephedrine hydrochloride and chlorpheniramine Maleate tablets and Group B (114 cases)were treated with paracetamol pseudoephedrine hydrochloride and chlorphenamine maleate tablets.The method to take the medicine was one tablet three times a day for 3-5d.RESULTS: The total efficacy rate of Group A was 100%,with the total obvious effective rate of 98.21%;while the efficacy rate and the total obvious effective rate of Group B were 99.12%and 97.37% respectively .The results indi-cate that the difference between the efficacy rates of the 2 groups had no statistical significance (P>0.05). The occurrence rate of the adverse reaction in Group A and Group B was 20.18% and 24.79% respectively (P>0.05).CONCLUSION: Both ibuprofen pseudo-ephedrine hydrochloride and chlorpheniramine Maleate tablets and paracetamol pseudoephedrine hydrochloride and chlorphenamine maleate tablets are safe and effec-tive medicine in the treatment of upper respiratory symptoms caused by cold.

Key words: ibuprofen pseudoephedrine hydro-chloride and chlorpheniramine Maleate tablets, parac-etamol pseudoephedrine hydrochloride and chlorphena-mine maleate tablets, cold

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