Effects of synthetic musk on clotting-time and platelet aggregation rate in acute blood-stasis model rats

Abstract

Abstract: AIM: To study the effects of synthetic musk on clotting-time and platelet aggregation rate in acute blood-stasis model rats. METHODS: The acute blood-stasis model rats were made by soaked ice water after injection of adrenalin hydrochloride in a major dose. Compound salvia tablet was intragastrically administered in positive control group. After management, the clotting-time and platelet aggregation rate were observed. RESULTS: Compared with the model group, after administration of synthetic musk the maximum percentage of platelet aggregation was palliated significantly(P <0.01 or P <0.05).Compared with the model group, after administration of high dose synthetic musk the TT, PT and APTT (indexes of clottingtime) were prolonged significantly(P <0.05). CONCLUSION: Synthetic musk can inhibit the platelet aggregation, prolong the clotting-time and ameliorate the abnormality in hemorheology.

Key words: synthetic musk, acute blood-stasis model, platelet aggregation, clotting-time

CLC Number:

R965.1

LI Hai-tao, LI Jie, CHEN Tao, JI Shui-ling. Effects of synthetic musk on clotting-time and platelet aggregation rate in acute blood-stasis model rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(9): 1004-1007.

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