Study between related factors of hepatocellular carcinoma and ubiquitin proteasome pathway

Abstract

Abstract: Hepatocellular carcinoma is one of the largest causes of cancer-related deaths worldwide for which there are very limited effective treatment options. The ubiquitin-proteasome pathway (UPP) has rapidly become acknowledged as both critical mechanism for cellular biological function and a latent target of regulation of cancer- related disease. This review focus on the role of ubiquitin-proteasome pathway in hepatocellular carcinoma and its correlation factors (HBV 、P27 、 NF-κB, et al), in order to find novel therapeutic interventions against the genesis and development of hepatocellular carcinoma.

Key words: hepatocellular carcinoma, ubiquitinproteasome pathway (UPP), HBV, P27, NF-κB

CLC Number:

R966

WANG Shuai, CHU Liang, HU Xiao-wei, YAO Ji-hong. Study between related factors of hepatocellular carcinoma and ubiquitin proteasome pathway[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(9): 1068-1073.

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