Abstract: AIM: To study the protective effects of different doses Omeprazole on the toxic acute gastric mucosal lesion in rats. Meanwhile, the protective effects were investigated. METHODS: Forty rats were separated into blank control group, acute intoxication control group, low dose omeprazole treatment group, high dose omeprazole treatment group. Ulcer index was calculated, plasma ET, serum TNF-α and cholinesterase activity were measured.With gastric mucosa HE staining, gastric mucosa pathological changes were observed also. RESULTS: A toxic acute gastric mucosal lesion model were established on rats. Omeprazole could prevent rats from acute gastric mucosal lesion induced by poisoning, improve related indexes and pathological states as well; large dose omeprazole could be more beneficial for acute gastric mucosal lesion induced by poisoning. CONCLUSION: Administration of Omeprazole could improve the acute gastric mucosal lesion induced by orgnaophosphorus pesticide orally in rats, and large dose Omeprazole could be more beneficial;ET and TNF-α in serum could be considered as the surrogate for treatment of acute poisoning gastric mucosal lesion induced as well as index for early detection.

Key words: Omeprazole, Endothelin, Tumor necrosis factor, Organophosphate poisoning, Acute gastric mucosal lesion