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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2011, Vol. 16 ›› Issue (12): 1321-1325.

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Study on the relationship between pharmacokinetics and pharmacodynamics for statins in hyperlipidemia model in rats

LI Jing-yuan1, CAI Jia-li1, DAI Ren-ke2, XIE Shui-lin2, DENG Ji-feng3, LU Pei-feng3, LI Ren-shu4, SUN He4, LIU Yan-huai5   

  1. 1School of Pharmaceutical and Biological Engineering, Chongqing University of Technology, Chongqing 400050, China;
    2School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, Guangdong, China;
    3Zhongshan PharmaSS Co,.Ltd, Zhongshan 528437, Guangdong, China;
    4School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China;
    5East Linden Co,.Ltd, Beijing 100191, China
  • Received:2011-07-27 Revised:2011-11-26 Online:2011-12-26 Published:2012-01-07

Abstract: AIM: To explore the relationship between exposure level (such as pharmacokinetics parameters) and pharmacodynamics for statins in hyperlipidemia model in rats.METHODS: The hyper- lipidemia rat model was established with the method of diet-induced, and the rats were given different does of statins to treat. The pharmacokinetics and pharmacodynamics parameters were determined, and the value of PK/PD were calculated, and their correlations were analyzed.RESULTS: TG-AUC showed a good linear relationship at the range of 0-10.96 folds, Y=0.01036X-7.6445 (γ=0.9599), the intermediate data such as CHOL-AUC, LDL-C-AUC, HDL-C-AUC were on the low side, which resulted large deviation, so there was an extremely weak linear correlation in these groups.CONCLUSION: There was a good linear relationship between TG and AUC in the range of AUC (0-10.96 folds), it could be efficaciously used to predicted the pharmacodynamics upon the related datas for AUC.

Key words: Hyperlipidemias, Predictive model, Pharmacokinetics, Pharmacodynamics, Statins

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