Association of polymorphism in CRP gene with metabolic syndrome

Abstract

Abstract: AIM: To investigate the association of rs6677719 polymorphism in the C-reactive protein gene with metabolic syndrome.METHODS: Stratified cluster sampling method was conducted to select 301 cases of metabolic syndrome and 547 healthy individuals who were matched with cases for age and gender from a community based population.Questionnaire was managed, and physical examination and blood biomarkers tests were conducted, and rs6677719 locus was detected by the method of polymerase chain reaction-restriction fragment length polymorphism (RFLP).The distributions of TT, TC and CC genotype frequencies between cases and controls were compared and the association of rs6677719 polymorphism with serum glucose, blood pressure and blood lipids were analyzed.RESULTS: The results of association analysis indicated that rs6677719 variation had significant correlation with MS, and additive and dominant models presented statistical significances, odds ratios (OR) and corresponding 95% confidence interval (CI) were 0.785 (0.640-0.862) and 0.659 (0.489-0.889) ,respectively.The TG level of TC genotype carrier was significantly lower than that of TT genotype carrier in control group.Furthermore, the HDL-C and LDL-C levels of individuals presented significant linear trend in TT, TC and CC genotypes.CONCLUSION: The results in the present study suggest that rs6677719 polymorphism in CRP gene is associated with MS and the genetic variation significantly affects the TG, HDL-C and LDL-C of metabolisms in general population.

Key words: Metabolic syndrome, C-reactive protein, Association study

CLC Number:

R968

JIN Yue-long, HE Lian-ping, CHEN Jin-feng, WANG Bin-bin, SHEN Chong, YAO Ying-shui. Association of polymorphism in CRP gene with metabolic syndrome[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(12): 1391-1396.

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