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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2011, Vol. 16 ›› Issue (12): 1419-1422.

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Dosage research of serum 25-hydroxyvitamin D levels on different intervention treatments for children

ZHANG Xia-juan1, BAO Li-fang1, BAO Zhou-jun2, WANG Yin2, LI Yi-wei2, WANG Ye-kai3   

  1. 1Child Health Department,the Maternal and Child Care Service Centre of Zhoushan,Zhoushan 316000,Zhejiang,China;
    2Clinical Laboratory,Zhoushan Hospital, Zhoushan 316004,Zhejiang,China;
    3Molecular and Biology Laboratory,Zhoushan Hospital, Zhoushan 316004,Zhejiang,China
  • Received:2011-09-27 Revised:2011-12-03 Online:2011-12-26 Published:2012-01-07

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Abstract: AIM: To explore the serum 25-hydroxyvitamin D levels effected by different intervention treatments.METHODS: 102 children with vitamin D deficiency were selected and divided as follows: Group A: VitD 150000 IU once; Group B: VitD 200000 IU once; Group C: VitD 300000 IU once; Group D: VitA 3600 IU+VitD 2000 IU per day, lasting for a month. A month later, their serum 25-hydroxyvitamin D levels were rechecked by electrochemistry method.RESULTS: The serum 25-hydroxyvitamin D levels after treated in Group A,B,C,D were significantly higher than that before treated(P＜0.01). The increased serum 25-hydroxyvitamin D levels in Group A,B and C were significantly higher than that in Group D(P＜0.01). The increased serum 25-hydroxyvitamin D levels in Group C was significantly higher than that in Group A and B(P＜0.01).CONCLUSION: VitD 150000-200000 IU once is a safe and effective intervention treatment for vitamin D deficiency.

Key words: 25-hydroxyvitamin D, Children with vitamin D deficiency, Electrochemistry method

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