Abstract: AIM: To evaluate the effect of lactobacillus in treating children acute diarrhoea. METHODS: By searching CENTRAL(the Cochrane central register of controlledtrials),Medline, EMBSE,CBM,CNKI and WANFANG et al, we collected both domestic and overseas published randomized controled trials about the effect of lactobacillus in treating children acute diarrhoea. The study subjects were children suffering from acute diarrhoea; the intervention was the lactobacillus; the control was placebo;and the outcome was the duration of acute diarrhoea, measured by sandard mean differece(SMD) and its 95% confidence interval (CI). The statistical heterogeneity was tested by cochran's chi-square test (Q test). The Egger test was used to test the publication bias. The data was analyzed by using statistic software Stata11.0. RESULTS: 7 trials that included a total of 945 patients were analyzed in the meta-analysi.479 children were in the lactobacillus group and 466 were in the placebo group.The pooled sandard mean differece for treating acute diarrhoea was -1.24[SMD=-1.24, 95%CI=(-2.21,-0.28),Z=2.54,P=0.01] in the lactobacillus group as compared with the control group. CONCLUSION: The lactobacillus has clinical effectiveness for treating children acute diarrhoea.

Key words: Lactobacillus, Acute diarrhoea, Meta-analyis