Abstract: AIM: To compare the effects of risperidone and olanzapine on plasma non-enzyme antioxidants levels in the schizophrenic patients. METHODS: Using randomized study, schizophrenic patients were divided into risperidone and olanzapine group respeetively for four weeks treatment, and evaluated by the Positive and Negative Syndrome Scale (PANSS). Serum levels of Albumins, Uric Acid, and Bilirubin were tested. RESULTS: (1)There were no difference between two groups about the levels of Albumins, Uric Acid, and Bilirubin before treatment and after 4 weeks treatment (P＞0.05). The levels of Albumins and Bilirubin after 4 weeks treatment in risperidone group were lower than those before treatment (P<0.05). The levels of Bilirubin after 4 weeks trea tment in olanzapine group were lower than tho se before treatment (P<0.05).(2)There were no difference between two groups about the effective rate (P＞0.05). CONCLUSION: Plasm a non-enzy meantioxidants levels in the schizophrenic patients changed after treatment, and there are no signif-icant differences in the effects of rispe ridone and olanzapine on plasma non-enzy me antiox idants levels.

Key words: Schizophreni, A lbumins, U ric Acid, Bilirubin, Olanzapine, Risperido ne