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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2011, Vol. 16 ›› Issue (9): 1057-1058.

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Effect of different doses of tropisetron in postoperative nausea and vomiting

ZHANG Hang, ZHANG Fan, LI Feng   

  1. Department of Anesthesiology, Wushan District, Hangzhou First People's Hospital, Hangzhou 310002, Zhejiang, China
  • Received:2011-07-19 Revised:2011-08-30 Online:2011-09-26 Published:2020-09-16

Abstract: AIM: To study the analgesic effect of different doses of tropisetron in preventing postoperative nausea and vomiting. METHODS: ASA grade Ⅰ-Ⅱ score of 150 cases, which was admitted for elective thoracic surgery in our hospital from January 2005 to December 2010, were divided into A, B, C three groups, n=50, A group using the analgesia adding 5 mg tropisetron, B group using the analgesia with 10 mg tropisetron, C group using 0.9% saline, compared the postoperative nausea and vomiting efficacy and adverse drug reactions of three groups of patients. RESULTS: A, B groups had no significant efficacy differences in the prevention of postoperative nausea and vomiting, but were significantly better than C group, P<0.05. The adverse reactions of A, B groups were significantly more than C Group, P<0.05, but can be tolerated.P<0.05. A, B groups of adverse reactions was significantly more than Group C, P<0.05, but can be tolerated. CONCLUSION: The analgesic effects in preventing postoperative nausea and vomiting of 5 mg, 10 mg tropisetron are more satisfied, and adverse reactions can be tolerated.

Key words: Postoperative nausea and vomiting, Tropisetron

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