Polymorphism of CYP2D6 gene and the influence on the metabolism of metoprolol

Abstract

Abstract: As one of major cytochrome P450s, CYP2D6 is responsible for the metabolism of many important drugs. Genetic polymorphism of CYP2D6 is the basis of lager interindividual and racial variability in the metabolism of drug. Metoprolol is a selective β₁-adrenoceptor antagonist, there is an obvious individual difference in clinic. It is metabolized in the liver, in vivo data indicate that approximately 70% of the metabolism of metoptolol depends upon CYP2D6. Genetic polymorphism of CYP2D6 have a great influence on the metabolism of metoprolol. Here we summarize the polymorphism of CYP2D6 gene and the influence on the metabolism of metoprolol.

Key words: Metoprolol, CYP2D6, Gene polymorphism, Drug metabolism

CLC Number:

R969.1

XIONG Dan, XIONG Yu-qing. Polymorphism of CYP2D6 gene and the influence on the metabolism of metoprolol[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(9): 1059-1064.

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