Abstract: AIM: To determine pharmacokinetics parameters of Shenfu injection with pharmacodynamics effect.METHODS: Model of acute cardiogenic shock was made by ligating left coronary artery. Mean blood pressure (MBP) was as effective index. Dose-response curves were established with 1.25,2.5,5,10,20,25 mL/kg six doses and time-course effects were established with the 20 mL/kg dose. The time- stock of organisms curves were calculated with the time-course effects and dose-response curves. The pharmacokinetic parameters of Shenfu injection were analysed with DASver2.0 software.RESULTS: The main pharmacokinetics parameters were:t_1/2=8.685 min, K_e=0.08 min^-1, CL=1.417 L·min^-1·kg^-1, AUC_(0-t)=12.63 mg·L^-1·min^-1.CONCLUSION: Apparent pharmacokinetic of Shenfu injection in rats fit one compartment

Key words: Shenfu injection, Pharmacokinetics , Pharmacodynamics effect method