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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2012, Vol. 17 ›› Issue (1): 69-72.

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Study on determining pharmacokinetics parameters of Shenfu injection by pharmacology effect method

DU Ting1, SUN Rong-jin2, XU Guo-liang1, LI Bing-tao1, HUANG Li-ping3, LI Jia1   

  1. 1Key Laboratory of Modern Preparation of Traditional Jiangxi University of Traditional Chinese Medicine, Nanchang 330004,Jiangxi,China;
    2Hubei University of Medicine, Shiyan 442000,Hubei,China;
    3College of Pharmacy,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,Jiangxi,China
  • Received:2011-10-24 Revised:2011-12-09 Online:2012-01-26 Published:2012-02-16

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Abstract: AIM: To determine pharmacokinetics parameters of Shenfu injection with pharmacodynamics effect.METHODS: Model of acute cardiogenic shock was made by ligating left coronary artery. Mean blood pressure (MBP) was as effective index. Dose-response curves were established with 1.25,2.5,5,10,20,25 mL/kg six doses and time-course effects were established with the 20 mL/kg dose. The time- stock of organisms curves were calculated with the time-course effects and dose-response curves. The pharmacokinetic parameters of Shenfu injection were analysed with DASver2.0 software.RESULTS: The main pharmacokinetics parameters were:t1/2=8.685 min, Ke=0.08 min-1, CL=1.417 L·min-1·kg-1, AUC(0-t)=12.63 mg·L-1·min-1.CONCLUSION: Apparent pharmacokinetic of Shenfu injection in rats fit one compartment

Key words: Shenfu injection, Pharmacokinetics , Pharmacodynamics effect method

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