Abstract: AIM: To study the effects of butorphanol , pethidine and tramadol in treatment of patients with perioperative shivering. METHODS: Sixty ASAⅠ-Ⅱ patients with shivering response during anesthesia were randomly divided into three groups(n=20): butorphanol group (group B), intravenous injection of butorphanol 0.02 mg/kg; pethidine group (group P), intravenous injection of pethidine 0.5 mg/kg; and tramadol group (group T), intravenous tramadol 1 mg/kg. Observed the degree and time of occurrence of shivering, shivering response after treatment and adverse effect in sedation score. RESULTS: Butorphanol group and tramadol group were effective than pethidine group in treatment of shivering(P<0.01). Butorphanol group was significantly higher than tramadol group and pethidine group in sedation(P<0.05).Tramadol group was significantly higher than pethidine group and butorphanol group in incidence of nausea and vomiting(P<0.05).CONCLUSION: Butorphanol and tramadol can effectively treat perioperative shivering,but clinical patients should be reasonable select different drugs according to particular case.

Key words: Butorphanol, Tramadol, Pethidine, Shivering