Therapeutic effects of benthiacthiactzine against circulatory failure induced by methomyl

Abstract

Abstract: AIM: To investigate the therapeutic effects of benthiactzine against circulatory failure induced by methomyl in rats. METHODS: Thirty-six healthy SD male rats, were divided into four groups randomly: methomyl poisoning rats treated with benthiactzine or atropine by i.m.Rats were treated with methomyl (i.p) to induce circulatory failure in which the mean blood pressure (MBP) dropped to 40-45 mm Hg as an index, then treated with benthiactzine or atropine. The changes of peripheral blood pressure,cardiac function and Electrocardiographic were observed before and circulatory failure. RESULTS: In circulatory failure rats induced by methomyl, the peripheral blood pressure, HR, and cardiac systolic function parameters were decreased significantly (P<0.01), while cardiac diastolic function parameters were increased dramatically (P<0.01). The electrocardiogram of circulatory failure rats showed bradycardia, nodal rhythm and sharp T wave. After treated with benthiactzine 0.25-1.0 mg/kg or atropine 1.0 mg/kg, the peripheral blood pressure was increased markedly in 1 min (P<0.05 and P<0.01 respectively) and remained stable during 60 minutes experimental period. After treated 0.5-2 min, all hemodynamic parameters were improved significantly (P<0.05,P<0.01). The electrocardiogram was ameliorated in 1 min and restored to normal level in 3 min.CONCLUSION: Treated with benthiactzine, methomyl poisoning rats can get away from circulatory failure in a short time. Benthiactzine can be a favourable medicine against circulatory failure induced by methomyl.

Key words: Benthiactzine, Circulatory failure, Methomyl

CLC Number:

R541.6

WANG Ru-huan, SHI Yong-ping, JIN Xin, LONG Chao-liang, CUI Wen-yu, ZHANG Yan-fang, PAN Zhi-yuan, WANG Hai. Therapeutic effects of benthiacthiactzine against circulatory failure induced by methomyl[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(12): 1327-1332.

References

[1] 孙洪涛. 氨基甲酸酯类农药中毒30例临床病例分析及抢救体会[J].临床医学,2010,14(14): 43.
[2] 杨淑君. 氨基甲酸酯类农药中毒致深度昏迷抢救的护理体会[J].中国伤残医学,2010,18(3):143.
[3] 高殿利. 农药中毒抢救中阿托品过量中毒诊治分析[J].临床医学,2011, 24(9):5880.
[4] Liu N,Cao JW,Long CL,et al.Therapeutic effects of benthiacthiactzine against circulatory failure induced by tabun and cardiogenic shock by procainamide in dogs[J]. Chin Pharmacol Bull,2008,24(12):1623-1628.
[5] Luo W,Ge X,Cui W,et al.Targeting cholinesterase inhibitor poisoning with a novel blocker against both nicotinic and muscarinic receptors[J]. Neurotox Res,2010,18(2):173-186.
[6] 崔文玉,张雁芳,潘志远,等.宾赛克嗪拮抗M和N胆碱受体的特征及其抗胆碱酯酶抑制剂的毒性效应[J].中国药理学通报,2011,27(7): 915-921.
[7] 莫晨,龙超良,王汝欢,等.宾赛克嗪预防胆碱酯酶抑制剂中毒呼吸衰竭的实验研究[J].中国临床药理学与治疗学,2010,15(2): 135-139.
[8] 张津津,龙超良,唐渊,等.神经性毒剂梭曼中毒致犬心电图的变化及宾赛克嗪的救治作用[J].中国临床药理学与治疗学,2008,13(8): 886-890.
[9] 刘念,曹洁玮,王汝欢,等.宾赛克嗪对有机磷农药所致循环衰竭的救治作用[J].中国临床药理学与治疗学,2007,12(5): 575-581.
[10] 龙超良,王汝欢,张雁芳,等.胆碱酯酶抑制剂沙林诱发犬循环衰竭时血液内心血管活性物质的变化以及抗毒剂的对抗效应[J].中国临床药理学与治疗学,2006,11(3): 266-269.
[11] 李光,龙超良,慕邵峰,等.胆碱酯酶抑制剂类神经性毒剂诱导的犬循环衰竭救治前后血流动力学及血液内血管活性物质的变化[J].中国临床药理学与治疗学,2004, 9(2): 149-152.
[12] Kassa J,Krejeova G.Neuroprotective effects of currently used antidotes in tabun-poisoned rats[J]. Pharmacol Toxicol,2003,92(6): 258-264.
[13] Sevelova L,Vachek J.Effect of methoxime combined with anticholinergic,anticonvulsant or anti-HCN drugs in tabun-poisoned mice[J]. Acta Medica (Hradec Kralove),2003,46(3): 109-112.
[14] 莫晨,王汝欢,龙超良,等.大鼠DDVP中毒急性肺损伤模型的建立[J].武警医学院学报,2011,20(2): 88-90.