A Meta-analysis for hemorrheologic parameters in patients with cerebral infarction or high risk population treated by Shuxuetong or Danshen

Abstract

Abstract: AIM: To compare effects of Shuxuetong on hemorrheologic parameters to that of Danshen in patients with cerebral infarction or high risk population, so that evidences in Evidence-based Medicine can be provided for clinical pharmacotherapy. METHODS: Thirteen articles corresponding to our researching condition were searched out by retrieving and screening domestic articles from 2000 to 2011 according to the criterion for including or excluding articles. The data were processed by the method of meta-analysis. RESULTS: A comparison between Shuxuetong versus Danshen: HS [WMD=-0.53, 95%CI (-0.76, -0.31), P<0.05]; LS [WMD=-1.40, 95%CI (-2.05, -0.74), P<0.05]; PV [WMD=-0.27, 95%CI (-0.39, -0.15), P<0.05]; FIB [WMD=-0.75, 95%CI (-0.97, -0.52), P<0.05]; HCT [WMD=-0.05, 95%CI (-0.08, -0.01), P<0.05]. CONCLUSION: The improvement effects of Shuxuetong on hemorrheologic parameters are better than that of Danshen, even though serious heterogeneity exists among the selected articles.

Key words: Shuxuetong, Danshen, Hemorrheology, Cerebral infarction, High risk, Meta-analysis, Evidence-based medicine

CLC Number:

YAN Tao, ZHOU Qi-xin, FEI Hui-zhi, HU Xiao-ya, YANG Qiu-jun. A Meta-analysis for hemorrheologic parameters in patients with cerebral infarction or high risk population treated by Shuxuetong or Danshen[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(3): 302-307.

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