Abstract: AIM: To explore the influence of Ginseng Polysauharides on balance between Thromboxance B₂ and Prostacyclin F_1α during hepatic ischemia/reperfusion injury (HIRI) in rabbits.METHODS: Thirty rabbits were randomly divided into 3 groups:control group (Group C),ischemia/ reperfusion group (Group IR) and Ginseng Polysauharides group (Group GP). Thromboxance B₂(TXB₂), ProstacyclinF_1α(PGF_1α), TXB₂/PGF_1α and ALT of the three groups were measured in 10 minutes before ischemia, ischemia of 45 minutes and reperfusion after 45 minutes respectively, and the hepatocellular morphological changes were observed during HIRI in the electronic microscope.RESULTS: In Group IR, the content of TXB₂ in the plasma was obviously higher than that in Group C in the corresponding time point; the content of PGF_1α declined notably 45 minutes after reperfusion compared with 10 minutes before ischimia, TXB₂/PGF_1α increased significantly,the ultrastructure of hepatic cell was obviously abnormal. In Group GP, the content of TXB₂ declined a little and the PGF_1α increased compared with those in Group IR during reperfusion 45 minutes.TXB₂/PGF_1α were significantly higher than the ratio of Group IR, especially 45 minutes after reperfusion. The abnormal morphological changes of liver cells was ameliorated remarkably too during HIRI.CONCLUSION: Ginseng Polysauharides can regulate imbalance between TXB₂ and PGF_1α, and improve hepatic microcirculation, thus can prevent the hepatocell from the injury caused by hepatic ischemia reperfusion.

Key words: Ginseng Polysauharides, Liver, Reperfusion injury, Thromboxane B₂, Prostaglandin F_1α