Effect of CYP2C9, CYP2C19, CYP3A4 polymorphism on metabolism of sulfonyluea antidiabetic drugs

Abstract

Abstract: Sulfonylurea oral antidiabetic drugs were mainly metabolized by hepatic cytochrome P450 in human.Cytochrome P450 is one kind of important drug metabolizing enzymes in human and exhibits genetic polymorphism, which usually results in the difference of efficacy and adverse reaction among individuals.The purpose of this paper was to review the basic structure, genetic polymorphism and ethnic difference of CYP2C9, CYP2C19, CYP3A4 and the influence to sulfonylurea metabolism.

Key words: CYP2C9, CYP2C19, CYP3A4, Sulfonylurea antidiabetic drugs, Drug metabolism

CLC Number:

R968

LI Yun, HE Fang, ZENG Cai-wen, LIU Lin-lin, XIA Chun-hua. Effect of CYP2C9, CYP2C19, CYP3A4 polymorphism on metabolism of sulfonyluea antidiabetic drugs[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(5): 582-587.

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