Research progress in application of multi-component mixtures of enhancers in transdermal drug delivery

Abstract

Abstract: Research study showed that multi-component mixtures of enhancers had significant permeation enhancing ability than permeation enhancers alone, with low skin irritancy and low systemic toxicity. It can be concluded that multi-component mixtures of enhancers, will have a better development, while taking further research on permeation enhancement mechanism and high-throughput screening method. According to domestic and foreign literatures, application of multi-component mixtures of enhancers in transdermal drug delivery were presented. The review focused on the following aspects: (1) drug transport across skin; (2) permeation enhancement mechanism; (3) high-throughput screening of transdermal formulations and application practice.

Key words: Multi-component mixtures of enhancers, Synergistic effect, High-throughput screening, Transdermal drug delivery

CLC Number:

R943

YU Wen-ying, ZHANG Liang, CHEN Guo-shen, YE Jin-cui. Research progress in application of multi-component mixtures of enhancers in transdermal drug delivery[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(1): 103-109.

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