Abstract: AIM: To investigate the safety and efficacy of dexmedetomidine(DEX) combined with propofol for sedation of patients undergoing painless enteroscope. METHODS: Sixty six patients with ASA I-II requiring enteroscope were randomized to (Group D, n=33) and (Group P, n=33). After venous pass way was conducted, the mean arterial pressure(MAP), heart rate(HR),hemoglobin oxygen saturation levels(SpO₂)were recorded. Group D received DEX 0.1μg/kg and Group P received saline placebo 3 mL initial loading dose, followed by propofol 1.5mg/kg, according to the body activity and operation time, whether to add propofol 30-50 mg or not. And the consumed dose of propofol, the body movement response, respiratory depression were recorded. RESULTS: Compared with Group D, the total administered dose of propofol, the time of patients awaken, the body activity in Group P were increased. During the painless anesthesia, propofol could lead to the circulation inhibition and the heartbeat was significantly quickened. Dexmedetomidine has little influence on the circulation, but it induced the decreased of heart rate. CONCLUSION: There were more efficacy and safe for DEX combined with propofol for sedation of patients undergoing painless enteroscope.

Key words: Dexmedetomidine, Propofol, Painless enteroscope, Side effect