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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2013, Vol. 18 ›› Issue (1): 99-102.

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Research progress on pharmaceutical necessities affecting the cytochrome P450

OUYANG Dong-Sheng1,2, SHUAI Fang-Wen2, ZHOU Hong-Hao1   

  1. 1Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, Hunan, China;
    2Hunan Pharmaceutical Necessities Engineering Technology Research Center, Liuyang 410300, Hunan, China
  • Received:2012-06-05 Revised:2012-06-05 Published:2013-02-05

Abstract: Pharmaceutical necessities could affect the activity of cytochrome P450 enzyme(CYP1A2,CYP2C9,CYP2C19,CYP2D6 and CYP3A4) and further influence drug metabolism, efficacy and safety. The biological effect research of pharmaceutical necessities should be taken seriously. This paper summarizes the research progress through reading lots of domestic and overseas relative literatures carrying on the analysis and comprehensive.

Key words: Cytochrome P450, Pharmaceutical necessities, Interaction

CLC Number: