Abstract: AIM: To compare the curative effect of different methotrexate medication in ectopic pregnancy with different β-human chorionic gonadotropin (β-HCG) rising ratio.METHODS: A retrospective study was conducted on 90 patients treated with methotrexate intramuscular injection due to unruptured ectopic pregnancy. According to different pre-treatment β-HCG rising ratio(pre-treatment β-HCG rised more or less than 20% in 48 hours) and different methotrexate regimen(methotrexate 75 mg one dose intramuscular injection or 100 mg divided into five doses intramuscular injection),all the 90 patients were divided into four groups,and we compared the efficacy and side effects between groups.RESULTS: For patients whose pre-treatment β-HCG rised more than 20% in 48 hours,given 100 mg methotrexate divided into five doses intramuscular injection resulted in less repeat therapy(P<0.05) and shorter time for β-HCG levels to fall to normal(P<0.05).For patients whose pre-treatment β-HCG rised less than 20% in 48 hours,both two treatments had similar effection(P>0.05).However, receiving 100 mgmethotrexate divided into five doses intramuscular injection would result more side effects(P<0.05).CONCLUSION: For unruptured ectopic pregnancy,if the pre-treatment β-HCG rised rapidly, 100 mg methotrexate divided into five doses intramuscular injection would be more effective,but may cause more side-effects. If the pre-treatment β-HCG rised slowly, methotrexate 75 mg one dose intramuscular injection would be the preferred alternative.

Key words: Pregnancy,ectopic, Methotrexate, Therapy,non-surgical