Association between ABCA1 G2706A polymorphism and lipid-lowering treatment with atorvastatin

Abstract

Abstract: AIM: To investigate the association between ATP-binding cassette transporter A1 (ABCA1) gene single nucleotide polymorphism (SNP) and lipid-lowering efficacy of atorvastatin. METHODS: 105 patients with hyperlipid were treated with atorvastatin 20 mg per night for one month enrolled in this study (follow-up data were available in 90). Genotype were determined using polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). Serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) levels were determined before and after the treatment of one month. RESULTS: No significant association was found between ABCA1 G2706A polymorphism and TC, TG, LDL-C, HDL-C changes. CONCLUSION: ABCA1 G2706A polymorphism may be not associated with atorvastatin efficacy.

Key words: ATP binding cassette transporter A1 gene, single nucleotide polymorphism, statin

CLC Number:

R969.1

XIE Xiang-rong, WANG Ming, ZHENG Ya-jun, LI Jia-jia, ZHANG Xia, SUN Ling-ling, CHENG Lang, CAO Heng. Association between ABCA1 G2706A polymorphism and lipid-lowering treatment with atorvastatin[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(11): 1259-1262.

References 11

[1]	Nissen SE, Tuzcu EM, Schoenhagen P, et al.Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial[J]. JAMA, 2004, 291(9):1071-1080.
[2]	Okazaki S, Yokoyama T, Miyauchi K, et al.Early statin treatment in patients with acute coronary syndrome demonstration of the benefical effect on atherosclerotic lesions by serial volumetric intravascular ultrasound analysis during half a year after coronary event: ESTABLISH Study[J].Circulation,2004,110(9):1061-1068.
[3]	谢向荣,汪茗,张厚军, 等.阿托伐他汀对冠状动脉斑块退缩及其成分的影响[J].中国临床药理学与治疗学,2009,14(4) :438-442.
[4]	程丹,王国文.药物基因组学及生物芯片应用[J].实用药物与临床, 2008,11(2):114-115.
[5]	Lawn RM.ABCA1 the gatekeeper for eliminating excess tissue cholesterol[J]. Lipid Res,2001,42(8):1173-1179.
[6]	Frikke-Schmidt R,Nordestgaard BG,Jensen GB,et al.Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population[J].J Clin Invest,2004,114(9):1343-1353.
[7]	Benton JL,Ding J,Tsai MY,et al.Associations between two common polymorphisms in the ABCA1 gene and sub-clinical atherosclerosis:Multi-Ethnic Study of Atherosclerosis(MESA)[J].Atherosclerosis,2007,193(2):352-360.
[8]	中国成人血脂异常防治指南制订联合委员会.中国成人血脂异常防治指南[J].中华心血管病杂志,2007,35(5):390-416.
[9]	Klucken J,Buchler C,Orso E, et al.ABCG1(ABC8),the human homolog of drosophila white gene,is a regulator of macrophage cholesterol and phospholipid transport[J].Proc Natl Acad Sci USA,2000,97(2):817-822.
[10]	唐朝克. 以ABCA1为靶点防治动脉粥样硬化[J].中国动脉硬化杂志,2011,19(11):879-884.
[11]	Reieb J,Omezzine A,Rebhi L,et al.Associations between common polymorphisms of adenosine triphosphate-binding cassette transporter A1 and coronary artery disease in a Tunisian population[J].Arch Cardiovasc Dis,2010,103(10):530-537.

[1]	LI Qinghua, ZHAO Yan, ZHAO Haigang, GAO Pengfei, XU Bingxin. Value of ABCB1 G2677T gene polymorphism detection in lipid-lowering therapy with atorvastatin in patients suffered from ischemic stroke [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(6): 633-640.
[2]	ZHAO Lu, LI Fuyong, WEN Binhong, LI Daowei. Effects of stains on hyperlipidemia and pain relieve of patients with chronic migraine [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(6): 671-675.
[3]	TANG Zizhao, NIE Fangqin, YAN Xin, FU Yangxia, HUANG Jun, WANG Xia, GUO Ren. Effect of Atglistatin on PA-induced VSMCs proliferation and ATGL expression [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(1): 29-35.
[4]	WANG Shuang, LIU jia, ZHANG Yueli. Associations of POR*28 polymorphisms with tacrolimus stable dose in Chinese kidney transplantation patients [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(9): 991-997.
[5]	LIN Xueyan, LIN Zhihui, HUANG Huping. Effect of terlipressin on renal function in cirrhotic patients with esophageal gastric varices bleeding and normal baseline renal function [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(7): 775-784.
[6]	LIANG Meifang, CHEN Qingzhuang, YANG Peiqun, WANG Yong. Efficacy and safety of generic and branded atorvastatin in patients with ischemic stroke/transient ischemic attack: A real-world study [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(7): 785-792.
[7]	YUN Qiang, DONG Xuejia, WANG Mengjiao, LIU Yahong, WANG Zhiguang, JIANG Mingfang. Rosuvastatin regulates cerebral I/R damage to neurons by UCP2-SIRT3 signal [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2021, 26(2): 144-153.
[8]	WANG Fengling, MENG Xiangyun, CHEN Zhengxu, CAO Rongjuan, HE Zhengmin, YE Xi, WANG Cong, LI Qi. Analysis on genetic polymorphism of SLCO1B1 and ApoE in patients with cardiovascular diseases of Han nationality in Anhui area and its clinical significance for individualized use of statins [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2021, 26(1): 40-48.
[9]	YANG Ming, DONG Xiaowen, HONG Huashan. Statins for primary prevention of atherosclerotic cardiovascular disease in people 75 years of age and older [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(9): 1074-1080.
[10]	RU Caiwang, YUAN Tianming, YANG Bingfen, WU Fugen, LIN Yingrong, MO Miaojun. Effects of imipenem-cilastatin sodium combined with immunoglobulin on serum PCT, hs-CRP and TNF-α in children with baby sepsis complicated with disseminated intravascular coagulation [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(5): 559-565.
[11]	XIE Xiangmei, HUANG Zhihong, LIU Xiaoju, XUE Bing, LAN Baozhu. Effects of atorvastatin and folic acid tablets on homocysteine and carotid atherosclerosis in patients with type H hypertension [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(4): 455-459.
[12]	LI Jiadan，LU Chen. Synergistic effects of Cortex Mori alkaloids combined with Simvastatin in rats with hyperlipidaemia [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(3): 278-284.
[13]	Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, GCP Center Phase I Clinical Trial Ward, Shenyang , Liaonning, China. Bioequivalence of rosuvastatin calcium tablets in Chinese healthy subjects [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(12): 1369-1375.
[14]	SUN Qing, SUN Jianfang, LI Li, CHANG Huichao, ZHOU Quan. Effects of Wuzhi capsule on the pharmacokinetics of simvastatin and its metabolite simvastatin acid in rats [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(11): 1242-1249.
[15]	XUE Hua, LU Lili, XIANG Hui, QIAN Zhenhua. Curative efficacy of ulinastatin combined with hydrocortisone in treatment of severe sepsis secondary shock and effects on serum factor levels [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(3): 313-317.