Control research on fast up⁃titration of escitalopram in the treatment of generalized anxiety disorder

Abstract

Abstract: AIM: To explore wether fast up?titration of escitalopram can make patients with generalized anxiety disorder (GAD) response quicker and elevate the efficacy by the end of the 8th week. METHODS: 78 patients who meet ICD?10 criteria for GAD were divided into escitalopram fast up?titration group (n=36) and normal up?titration group(n=42) randomly. The trial lasted 8 weeks. The anxiety status and efficacy was evaluated with GAD?7(Generalized Anxiety Disorder Scale?7) on the baseline, 1st, 2th, 4th, 8th weekend respectively and the safety was evaluated by TESS and laboratory examination. RESULTS: The GAD?7 scores in fast up?titration group declined quicker than that in normal up?titration group by the end of 1st, 2th, 4th,8th week(P<0.05) respectively. The remission rate of fast up?titration group were 11.1%,27.8%,50.0%,72.2%, and response rate is 33.3%,50.0%,63.9%,88.9%,while the remission rate of normal up?titration group was 2.4%,11.9%,23.8%,50.0%, and response rate was 11.9%,26.2%,42.9%,66.7% at the end of 1st, 2th, 4th,8th weekend .The whole efficacy of fast up?titration group was better than normal up?titration group (P<0.05) .The side effects of both groups had no significant difference(P>0.05).CONCLUSION: Fast up?titration of escitalopram demonstrated to be more effective in the treatment of GAD, and response faster, while the safety is similar.

Key words: escitalopram, fast up?titration, generalized anxiety disorder, GAD?7

CLC Number:

R749.7⁺²

SHEN Zhong⁃xia, SHEN Xing⁃hua,CAI Min,FANG Yu,LIN Min, YANG Jian⁃hong, XU Yi. Control research on fast up⁃titration of escitalopram in the treatment of generalized anxiety disorder[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(11): 1263-1267.

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