Abstract: AIM: To observe the effects of dexmedetomidine on hemodynamics and intraocular pressure for laparoscopic gynecological surgery. METHODS: 80 (ASA I )patients who undergoing elective laparoscopic gynecological surgery were randomly divided into four groups (Group A, B, C, D),n=20 in each group , group A: anesthesia using the laryngeal mask, 10 min before the induction of anesthesia, intravenous infusion dexmedetomidine 0.6 μg/kg (infusion within 10 min); group B :laryngeal mask anesthesia, intravenous infusion 0.9% sodium chloride solution in the same way with group A; group C: anesthesia with tracheal intubation, the application of dexmedetomidine in the same way with group A; group D: anesthesia with tracheal intubation, intravenous infusion 0.9% sodium chloride solution in the same way with group C. The blood pressure (BP), heart rate (HR), intraocular pressure (IOP) were observed and recorded at time points of before induction of anesthesia (T₀), after induction of anesthesia (T₁), immediately after endotracheal intubation or laryngeal mask (T₂), and changes in position after pneumoperitoneum (T₃), tracheal extubation or laryngeal mask poll out instantly (T₄). RESULTS: MBP, HR, IOP had no significant differences among the four groups at T₀ . The incidence of hypertension, high intraocular pressure in group A were lower than those of group B, C, D (P<0.01) , in which group B, C were lower than that of group D (P<0.01 or P<0.05). CONCLUSION: Dexmedetomidine can help stabilize the perioperative blood pharmacokinetics and intraocular pressure of gynecologic laparoscopic surgery under general anesthesia especially in the case of using laryngeal mask, besides do not delay waking. It is worth promoting.

Key words: dexmedetomidine, hemodynamic, intraocular pressure, laparoscopic surgery