Abstract: AIM: To compare the curative effect and clinical influence factors of risperidone and olanzapine in the treatment of the acute phrase of schizophrenia.METHODS: 27 cases were treated with risperidone in a regimen of 2-6 mg/d.26 cases were treated with olanzapine in a regimen of 10-20 mg/d.Positive and Negative Syndrome Scale(PANSS) were used to measure the efficacy for 6 weeks.The patient's gender, age, duration before treatment and accurately record the patient's drug use were collected during treatment. RESULTS: The response rate at the end of 6 weeks of risperidone and olanzapine both were 84.6%. The general pathological symptoms and positive symptoms, the curative effects of olanzapine is better than those of risperidone(P<0.05). Risperidone and olanzapine curative effects in the treatment of the acute phrase of schizophrenia were increased with the extension of the treatment time(P<0.05). The treatment time had no interactions with risperidone and olanzapine(P>0.05). Treatment time, duration, dose, affected the efficacy of risperidone(P<0.05), treatment time affected the efficacy of olanzapine(P<0.05).CONCLUSION: The curative effect between olanzapine and risperidone has no difference,but the stablity of olanzapine is better than it of risperidone in the treatment of the acute phrase of schizophrenia.

Key words: risperidone, olanzapine, schizophrenia, acute treatment period, clinical factors