Effects of food on Cytochrome P450 drug metabolic enzymes

Abstract

Abstract: Cytochrome P450 (CYP450) enzymes play important roles in the biological oxidation process of many endogenous and exogenous moleculars, especially in drug metabolism. The great individual variations of the CYP450 enzymes among human subjects have been showed. In addition to the genetic factors, food and other environmental factors may also affect the activity and expression of CYP450 enzymes, which ultimately lead to the increased possibility of adverse reactions or toxicity. This review article summarizes the recent literatures with interests in the effects of food on cytochrome P450.

Key words: food, cytochrome p450, inhibition, induction

CLC Number:

R968

ZHANG Ran-ran, YANG Guo-ping, JING Ning-ning, HUANG Jie, HUANG Lu, WANG Yan. Effects of food on Cytochrome P450 drug metabolic enzymes[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(2): 200-205.

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