Research progress of aspirin resistance in diabetic statue

Abstract

Abstract: Aspirin is the “gold standard” of antiplatelet therapy. It plays a very important role in the prevention of cardiovascular disease. However, not all the patients can respond a consistent anti-aggregation effect after they take aspirin. Clinically, this phenomenon that therapeutic dose of aspirin can not prevent the cardiovascular events is called “aspirin resistance (AR)”. A considerable portion of aspirin resistance patients also have diabetes or insulin resistance. Many diabetic patients take aspirin for primary prevention of cardiovascular disease, but the benefit is low. Aspirin can reduce the risk of cardiovascular events by 41% in non-diabetic patients. But the risk reduction in the subgroup with diabetes was only 10%.Although diabetes has been recognised as a high risk factor of aspirin resistance, the mechanism under the high diabetic prevalence in aspirin resistance patients is unclear. This paper will review the mechanisms of aspirin resistance in diabetic statue and explore methods to reverse it.

Key words: diabetes, aspirin resistance, platelet

CLC Number:

R587.1

XIE Hao, ZHU Yu-mei, HAO Hai-ping, ZHENG Xiao, MA Si-jing, WANG Guang-ji. Research progress of aspirin resistance in diabetic statue[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(2): 233-240.

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