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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2014, Vol. 19 ›› Issue (6): 611-614.

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Pharmacodynamics effects of APPS Liposome on acute liver injury induced by D-galactosamine in experimental mice

LI Xiao-li1, DAI Wen-yun2, 3, SHI Sen-lin2, WU Jin-jin2, ZHU Yu-qing2   

  1. 1Shaoxing People’s Hospital, Shaoxing 312000, Zhejiang, China;
    2Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China; 3Sijiqing Street Community Health Center, Hangzhou 310016, Zhejiang, China
  • Received:2013-12-18 Revised:2014-05-20 Published:2014-07-01

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Abstract: AIM : To study the preventive and therapeutic effects of APPS Liposome on mice acute liver injury induced by D-galactosamine.METHODS: D-galactosamine was given to establish the acute liver damaged mouse models. ALT, AST in mice blood were examined as indexes to study on the anti-acute liver injury effect of APPS Polyphase liposome oral liquid, with bifendate as a control drug.RESULTS:High dosage of APPS Polyphase liposome(200 mg/kg)have a significant effect on the acute liver damaged mice models(P<0.05 or P<0.01), low dosage(50 mg/kg)has no significant effect on the models(P>0.05).CONCLUSION: The results indicated that preventive and therapeutic effects of APPS Polyphase Liposome on mice acute liver injury are significant.

Key words: APPS liposome, D-galactosamine induced liver injury, preventive and therapeutic effect 本

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