Research current situation and progress on pharmacogenomics and personalized medicine of cyclosporine A

Abstract

Abstract: Cyclosporine (CsA), as a novel potent immunosuppressant, is widely used in organ transplantation in recent years. Due to its narrow therapeutic index and individual difference, it has been greatly concerned that how CsA can be used rationally in clinic. The bioavailability and metabolic of CsA are mainly affected by drug-metabolizing enzymes CYP3A and P-glycoprotein transporter protein (P-gp), while the individual differences of gene polymorphism of CYP3A and multi-drug resistance gene (MDR1) are the molecular mechanisms of the generation of activity difference. In addition, the combination therapy, diet and other non-genetic factors are also an important reason for the therapeutic effect of CsA. This paper reviews the pharmacogenomics research of CsA combined with non-genetic factors, in order to provide reference for clinical individualized medicine so as to ensure safety and rational use of drugs on patients.

Key words: cyclosporin A, gene polymorphism, CYP3A, MDR1, combination therapy

CLC Number:

R969.1

DAI Ying, ZHANG Jing, LIN Mei-qing, SONG Hong-tao. Research current situation and progress on pharmacogenomics and personalized medicine of cyclosporine A[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(8): 931-936.

References 36

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