Endogenous cannabinoid system and Alzheimer Disease

Abstract

Abstract: Alzheimer's disease (AD) is a chronic progressing neurodegenerative disorder, and the principal neuropathological hallmark of the disease, is the extracellular β-amyloid peptide(Aβ) accumu- lation formed senile plaques, intracellular hyperphosphorylated tau formed neurofibrillary tangles, and loss of neuron with gliocyte proliferation. Recent evidence shows that endogenous cannabinoid system serve as preventive treatment for AD, based on their neuroprotective and anti-inflammatory effects. Here we summarizes several aspects of the endogenous cannabinoid protective effect of the AD, aiming at providing a new method for the treatment of AD.

Key words: endogenous cannabinoid system, 2-Arachidonoylglycerol, cannabinoid receptor, Alzheimer's disease

CLC Number:

R338
R322

DONG Man-man, YANG Hong-wei. Endogenous cannabinoid system and Alzheimer Disease[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(8): 943-947.

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