Abstract: AIM: To observe the effect of trazodone combined with psychotherapy for heroin addicts after detoxification, and to evaluate their effects in improving the psychological state and reducing relapse.METHODS: 120 heroin addicts receiving buprenorphine maintenance treatment(BMT) were randomly divided into control group (n=30 cases), trazodone group (n=30 cases), psychotherapy group (n=30 cases),and trazodone combined with psychotherapy group (n=30 cases). Patients in the respective groups were questionnaire surveyed by using Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), heroin craving rating scale, and self control scale before and after treatment.The course of treatment was 3 months.RESULTS: The single trazodone and the single psychotherapy could all reduce the anxiety and depression for heroin addicts after detoxification. Compared with the single trazodone group and the single psychotherapy group, the trazodone combined with psychotherapy group could reduce the anxiety and depression better. However, psychotherapy could significantly reduce the craving for heroin and improve self-control ability of addicts. The single trazodone also was effective in reducing craving for heroin and improving the self-control ability.CONCLUSION: Trazodone combined with psychotherapy is effective in reducing anxiety and depression for heroin addicts after detoxification. It can significantly reduce the craving for heroin and improve the self-control ability of addicts.

Key words: heroin addicts, anxiey, depression, craving, self-control