Effect of perioperative application of gabapentin on chronic pain of post-thoracotomy

Abstract

Abstract: AIM: To evaluate the effect of perioperative application of gabapentin on chronic pain of post-thoracotomy.METHODS: Seventy patients (ASA physical status Ⅰ-Ⅱ) undergoing elective thoracotomy were randomly divided into two groups: group A ( n=35) and B ( n=35). Group A received 300 mg of gabapentin 2 hours before operation, first day after operation beginning oral gabapentin for 300 mg, Tid, lasted until 10 days after; Group B received placebo, methods with the group A. Thoracic epidural anesthesia was performed using ropivacaine and sufentanil before general anesthesia. All patients received postoperative analgesia for 3 days. Patients were followed up 0.5, 2, 4, 6 months to assess chronic chest pain and quality of life conditions.RESULTS: At 0.5 and 2 months follow up, the incidences of chronic chest pain in group A were 52.8% and 36.1% respectively,those of group B were 57.1% and 42.9% respectively(P＞0.05). Similarly, at 4 and 6 months follow up, the incidences of chronic chest pain for groups A and B were 19.4%/13.9% and 25.7%/20.0% respectively(P<0.05). The incidence of chronic chest pain of group A was significantly less than that of group B at 4 and 6 months follow up after operation. Group A compared with group B, produced a shorter postoperative pain duration. The life satisfaction index B (LSI-B) scores between the two groups showed significant differences at the 6th month of follow-up.CONCLUSION: Perioperative oral gabapentin can effectively prevent and reduce the incidence of chronic chest pain of post-thoracotomy and improve the quality of life of patients.

Key words: gabapentin, chronic post-thoracotomy pain, quality of life, life satisfaction index B

CLC Number:

R614

FU Shuang, ZHOU Hui-dan, YUAN Xiao-hong, QU Pi-sheng. Effect of perioperative application of gabapentin on chronic pain of post-thoracotomy[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(5): 583-586.

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