Abstract: AIM: To explore the efficacy and side effects of hydrochloride oxycodone analgesia on colorectal cancer eradication surgery patients under patient controlled analgesia.METHODS: 120 colorectal cancer patients, ASA classifiation gradeⅠ-Ⅲ, were enrolled and randomly allocated into oxycodone group (Group O) and morphine group (Group M), each group had 60 cases. Patient controlled analgesia was initiated after the closure of surgical incision site in both groups. The following parameters (visual analogue scale, VAS), Ramsay sedation score, side effects related to opioids and patients' satisfaction on pain management) were observed and recorded in 1 h,4 h, 8 h,12 h,24 h and 48 h after initiation of patient controlled analgesia.RESULTS: No statistical significance was observed about VAS in resting and moving. Ramsay sedation scores of group O in 4 h,8 h and 12 h were significantly lower than those in group M (P﹤0.01, P﹤0.05). The cumulative incidence of vomiting in group O (11%) was markedly lower than that in group M (20%), and the same as incidence of respiratory depression (P﹤0.01).CONCLUSION: Oxycodone showed comparable effects for pain relief compared to morphine analgesia, it confers lower incidence of vomiting and respiratory depression. Based on the results, it is concluded that oxycodone may be useful as an alternative to morphine for PCA after surgery.

Key words: oxycodone, morphine, laproscopy, analgesia