Abstract: Warfarin is widely used as oral anticoagulant drug with narrow therapeutic window, wide variations in dose requirements and patients easily suffer from adverse event such as bleeding. Genetic factor can significantly influence on the stability of the warfarin dose and adverse events. The genes relate of pharmacokinetics, pharmacodynamics and drug transport all can influence on warfarin therapy. The article reviews the current research status of these genes and the progress of clinical application , aiming to comprehensive understanding of the genetic factors effect on warfarin therapy, Providing reference and guidance for personalized treatment.