Abstract:

AIM: To evaluate the clinical efficacy and safety of chaihu shugan powder combined with danshu capsule and xiaoyan lidan tablet in the treatment of post-cholecystectomy syndrome.  METHODS: Ninety patients with post-cholecystectomy syndrome were divided into control group (45 cases) and treatment group (45 cases) according to random number table method. The control group was given danshu capsule, 2 capsules /time, 3 times/d, and xiaoyan lidan tablet, 6 pills/time, 3 times/d, and the control group was given chaihu shugan powder, 1dose/d, on the basis of control group. After one month therapy, the clinical efficacy, clinical symptoms such as abdominal pain, abdominal distention, anepithymia, nausea and adverse reactions were observed in two groups, and self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to evaluate the patient's bad mood. RESULTS:The total effective rate 97.78% (44/45) in treatment group was higher than that of the control group 77.78%(35/45) (P<0.05). The scores of abdominal pain（0.94±0.52），abdominal distension（0.86±0.45），anepithymia（0.73±0.47）and nausea（0.72±0.41）in treatment group were significantly lower than the control group（2.62±0.51），（1.71±0.43），（1.51±0.52） and（1.41±0.45）(P<0.05).The scores of SAS（42.64±7.35）and SDS（32.37±7.09）in treatment group were significantly lower than the control group（50.31±8.62）and （48.41±7.11）(P<0.05). No obvious adverse reactions were found in two groups. CONCLUSION:Chaihu shugan powder combined with danshu capsule and xiaoyan lidan tablet in the treatment of post-cholecystectomy syndrome have better clinical curative effect, can improve clinical symptoms, increase patients' enthusiasm and bad no adverse reactions. It was worthy of clinical popularization and application.

Key words: post-cholecystectomy syndrome, chaihu shugan powder, danshu capsule, xiaoyan lidan tablet, bad mood, safety