Abstract:

AIM: To investigate the clinical effect of paroxetine hydrochloride combined with Danzhi xiaoyao pills in the treatment of depression associated with anxiety.  METHODS: Between March 2014 and March 2016, 160 patients with depression and anxiety in our hospital were selected as study subjects, randomly divided into experimental group and control group, each of 80 cases, the experimental group was given Pa Rossi Dean hydrochloride (20 mg/times, 1 times/d, according to the state of the disease gradually increased by 10mg per week to step by step, the therapeutic dose range of 20-60 mg/d) and Danzhi xiaoyao pills (oral, 6-9 g/time, 2 times/d) treatment, 8 weeks of continuous treatment, treatment effect, HAMA score, HAMD score, CGI score and adverse reactions of two groups were compared. RESULTS: The clinical total effective rate of the experimental group was 92.5%, significantly higher than that of 81.2% of the control group, the difference was statistically significant (P<0.05), there was no significant difference in recurrence rate between the two groups (P>0.05); 2 weeks, 4 weeks and 8 weeks after the treatment, HAMA, HAMD scores of the experimental group were significantly lower than the control group, the differences were statistically significant (P<0.05); There was no significant difference between the two groups before treatment (P>0.05), there was significant difference in CGI score 2 weeks, 4 weeks and 8 weeks after treatment (P<0.05); During the 8 week treatment, 24 patients (12.5%) in the experimental group were significantly lower than those in the control group (30%), and the difference was statistically significant (P<0.05), no significant difference was found between nausea, dry mouth, constipation, sweating, fatigue, palpitation, headache and other items (P>0.05). CONCLUSION: Clinical effect of paroxetine hydrochloride combined with Danzhi xiaoyao pills in the treatment of depression associated with anxiety show good tolerance to drugs, which is of high clinical value.

Key words: Paroxetine hydrochloride, Danzhi xiaoyao pills, depression associated with anxiety, clinical effect