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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2017, Vol. 22 ›› Issue (5): 538-544.

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Association study of NOS3 genetic polymorphism and the efficacy of anti-hypertensive drug treatment on patient with essential hypertension

JIN Yuelong 1, WANG Linhong 1, ZHU Lijun 1, LIANG Wei 1, DUAN Ying 1, YANG Song 3, CHEN Yanchun 3, ZHAO Xianghai 3, SHEN Chong 2, YAO Yingshui 1   

  1. 1 School of Public Health, Wannan Medical College,Wuhu 241002,Anhui,China;2 Department of Epidemiology&Statistics,School of Public Health,Nanjing Medical University 210029,Jiangsu,China;3 Department of Cardiology, Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing 214200, Jiangsu, China
  • Received:2017-01-09 Revised:2017-03-10 Online:2017-05-26 Published:2017-05-27

Abstract:

AIM: To evaluate the effect of NOS3 gene polymorphism on anti-hypertensive drug treatment for patient with essential hypertension (EH). METHODS: General information and Clinical biochemical indicators of EH patients taking compound reserpine, hypertension pill and Zhenju hypertension pill were collected. RELP-PCR was used to test the polymorphism of NOS3 gene (rs4496877, rs1808593 and rs3918186).A quantitative trait analysis was performed to evaluate the relation between NOS3 genetic variation and blood pressure taking different anti-hypertensive drugs. RESULTS: Quantitative trait analysis showed significant differences in diastolic blood pressure (DBP) among the genotypes (TT,TG and GG) of rs1808593 in patients taking the hypertension pill after adjusting covariants (P=0.035). Stratification analysis indicated that DBP of male patients taking the hypertension pill significantly decreased with the variation (T>G) of rs1808593 (P=0.046). For patients (age≥55) taking the hypertension pill, DBP of genotype TT was significantly higher than genotypes TG and GG of rs1808593(P=0.008). CONCLUSION: NOS3 gene rs1808593 mutation might relate to the anti-hypertensive effect of the hypertension pill.

Key words: NOS3 gene, gene polymorphisms, essential hypertension, drug efficacy

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