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Mechanism of the inhibition of apoptosis by survivin during high fluence low-power laser irradiation-induced apoptosis

CHU Jiru, SHEN Jie   

  1. Department of Clinical Pharmacy, Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui, China
  • Received:2017-03-31 Revised:2017-05-26 Online:2017-06-26 Published:2017-06-26

Abstract:

AIM: Recent years,some studies showed that high fluence low-power laser irradiation (HF-LPLI) can induce apoptosis whereas whether survivin plays an important role in this process and its regulation mechanism is not clear.This article mainly studies the distribution of survivin in nuclear and cytoplasm and the change of expression of survivin under the HF-LPLI treatment.  METHODS: The research real-time monitors the dynamic process of survivin under the HF-LPLI treatment with the GFP-survivin in ASTC-α-1 cells. RESULTS: The results showed that survivin translocated to nuclear at 3 hours and the expression quantity of survivin advances with time by LPLI(240 J/cm2). CONCLUSION: The results implicated that survivin may be regulated by HF-LPLI and regulates some cell signaling proteins,for instance,p53,Akt.The further study will explore that survivin regulate the precise transcription factors and the regulation mechanism.

Key words: survivin, apoptosis, high fluence low-power laser irradiation

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