Abstract:

AIM: To explore the effects of rivaroxaban combined with Xuesaitong injection on deep venous thrombosis (DVT) formation of lower extremity after spinal trauma surgery and its effects on blood coagulation function, blood rheology and other blood biochemical indexes.  METHODS: One hundred and five patients undergone spinal surgery in our hospital were divided into the treatment group and control group 1, control group 2 according to the different treatment methods after surgery, with 35 cases in each. After surgery, the control group 1 was given Xuesaitong injection therapy; the control group 2 was given rivaroxaban, while the treatment group was treated with rivaroxaban intervention and Xuesaitong injection therapy. The changes of coagulation function, hemorheology index and other blood biochemical indexes were detected and compared among the three groups. The incidence of DVT in three groups was evaluated and compared among three groups five days after surgery. RESULTS: After treatment, the PT, APTT and TT of the three groups were significantly prolonged compared with those before treatment; the FIB level was significantly lower than that before treatment (P<0.05 or P<0.01), and the difference among the three groups was significant (P<0.05 or P<0.01). After treatment, the whole blood viscosity, hematocrit, erythrocyte rigidity index of three groups were significantly lower than those before treatment; erythrocyte deformation index was significantly higher than that before treatment (P<0.05 or P<0.01), and the difference among three groups was significant (P<0.05 or P<0.01). After treatment, the levels of PLT and ET in the two groups were significantly higher than those before treatment, the D-D level was significantly lower than that before treatment (P<0.01), and there was significant difference among the three groups (P<0.05 or P<0.01). There was no significant difference in Hb level before and after treatment and among three groups (P>0.05). The incidence of DVT in the treatment group was 2.86%, which was significantly lower than 14.28% in control group 1 and 11.42% in control group 2 (P<0.05). CONCLUSION: Rivaroxaban combined with Xuesaitong injection can safely improve the coagulation function, blood rheology and other blood biochemical indexes, and effectively prevent the formation of DVT after spinal surgery.

Key words: spinal trauma, deep venous thrombosis, rivaroxaban, Xuesaitong injection, blood coagulation function