Effects of subclinical hypothyroidism on the outcome of in vitro fertilization and embryo transfer

doi:10.12092/j.issn.1009-2501.2018.05.012

Abstract

Abstract:

AIM: To investigate the effects of in vitro fertilization (IVF) on embryo acquisition in patients with subclinical hypothyroidism. METHODS: A total of 249 human subjects who received in vitro fertilization and embryo transfer (IVF-ET) for the first time in the reproductive medicine center of Wannan Medical College affiliated Yijishan Hospital from June 2014 to October 2017 were included and divided into two groups, with 67 cases of subclinical hypothyroidism, and 182 cases of normal thyroid function. Patients with subclinical hypothyroidism received levothyroxine sodium tablets at the beginning of treatment. Retrospective analysis was used to compare the number of retrieved oocytes, MII eggs, fertilization rate, cleavage rate, rescue ICSI rate, and high quality embryo rate between two groups. RESULTS:There were significant differences in fertilization rate, cleavage rate and salvage ICSI rate between the two groups (P＜0.05), but there was no significant difference in the number of retrieved oocytes, the number of MII eggs and the rate of high quality embryos (P＞0.05). CONCLUSION: Though patients with subclinical hypothyroidism received treatment to maintain TSH≤2.5 mIU/mL, they may still present lower fertilization rate, cleavage rate and higher rescue ICSI rate, hence drug maintenance is essential for subclinical hypothyroidism to maintain thyroid function.

Key words: subclinical hypothyroidism, in vitro fertilization embryo transfer, embryo outcome

CLC Number:

R581.2
R321

HU Weihua, YAN Yongxu, RUAN Jian, HOU Wenwen. Effects of subclinical hypothyroidism on the outcome of in vitro fertilization and embryo transfer[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(5): 552-556.

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