Effects of trimetazidine on serum-homocysteine and serum-gamma-glutamyl transferase level in the cases of stable angina cordis

doi:10.12092/j.issn.1009-2501.2018.08.014

Abstract

Abstract:

AIM: To investigate the effect of trimetazidine on serum-homocysteine and serum-gamma-glutamyl transferase level in the cases of stable angina cordis. METHODS: A total of 80 cases of stable angina cordis patients were included into this study. Conventional drug therapy for coronary heart disease was used for all the patients. In the treatment group, the additional therapy of 6-month trimetazidine was used. Serum-homocysteine and serum-gamma-glutamyl transferase levels were detected before and after treatment. RESULTS:Compared with data collected before treatment, serum-homocysteine and serum-gamma-glutamyl transferase levels in all the patients were significantly decreased after the 6-month therapy. However, more decreases were found in serum-homocysteine and serum-gamma-glutamyl transferase levels in the patients with additional 6-month trimetazidine as compared with the control group.CONCLUSION: Routine treatment plus trimetazidine can effectively reduce the serum-homocysteine and serum-gamma-glutamyl transferase levels and improve patients-outcomes for the patients with stable angina cordis.

Key words: stable angina cordis, trimetazidine, homocysteine, gamma-glutamyl transferase

CLC Number:

R541.4

SHENG Yang, ZHANG Tianjie. Effects of trimetazidine on serum-homocysteine and serum-gamma-glutamyl transferase level in the cases of stable angina cordis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(8): 922-926.

References

［1］谷彬，袁琼，刘思妤. 拉西地平对同型半胱氨酸诱导的内皮细胞功能损伤的保护作用［J］. 中国临床药理学与治疗学，2016，21(1): 10-15.
［2］刘会娟，雍小兰，何冠军，等. 硫化氢、同型半胱氨酸和环格列酮对胱硫醚-γ-裂解酶基因及蛋白表达的影响［J］. 中国临床药理学与治疗学, 2015, 20 (11): 1250-1255.
［3］Schaffer A, Verdoia M, Barbieri L, et al. Impact of diabetes on homocysteine levels and its relationship with coronary artery disease: a single-centre cohort study［J］. Ann Nutr Metab, 2016, 68(3): 180-188.
［4］陈子斌, 陆士娟, 李强. 同型半胱氨酸血症、胰岛素抵抗和超敏C-反应蛋白与高血压前期相关性分析［J］.中国现代医学杂志, 2018, 28(6): 90-93.
［5］Onat A, Can G, Ornek E, et al. Serum gamma-glutamyltransferase: independent predictor of risk of diabetes, hypertension, metabolic syndrome, and coronary disease［J］. Obesity (Silver Spring), 2012, 20(4): 842-848.
［6］马东芹, 郭晖, 吕欣航, 等. 2型糖尿病患者血尿酸与血脂、血清谷氨酰转肽酶的相关性［J］.中国老年学杂志, 2015, 35(9): 2421-2423.
［7］Tuunanen H, Engblom E, Naum A, et al. Trimetazidine,a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilatedcardiomyopathy［J］. Circulation, 2008, 118: 1250-1258.
［8］El-Kady T, El-Sabban K, Gabaly M, et al. Effects of trimetazidine on myocardial perfusion and the contractile response of chronically dysfunctional myocardium in ischemic cardiomyopathy: a 24-month study［J］. Am J Cardiovasc Drugs, 2013, 5: 271-278.
［9］Hankey GJ, Eikelboom JW. Homocysteine and vascular disease［J］. Lancet, 1999, 354(9176): 407-413.
［10］Cybulska B, Klosiewicz-Latoszek. Homocysteine-is it still an important risk factor for cardiovascular disease［J］. Kardiol Pol, 2015,73(11): 1092-1096.
［11］沈飞燕, 汪自龙, 张政, 等. 盐酸曲美他嗪片治疗心绞痛患者的疗效及对白介素6与脑钠肽水平的影响［J］. 疑难病杂志, 2016, 15(1): 27-30.
［12］王伟. 厄贝沙坦联合万爽力治疗扩张型心肌病心力衰竭临床效果观察［J］. 临床医学研究与实践, 2017, 2(4): 52-53.
［13］王莉莉. 万爽力对缺血性心肌病老年心力衰竭患者神经内分泌因子、左室重构及心功能的影响［J］. 临床医学工程. 2015, 8(12): 334-336.
［14］中华医学会心血管病学分会. 慢性稳定性心绞痛诊断与治疗指南［J］. 中华心血管病杂志, 2007, 10(3): 195-206.
［15］Robert C, Leslie D, Killian R, et al. Hyperhomocysteinemia: an independent risk factor for vascular disease［J］. N Engl J Med, 1991, 324: 1149-1155.
［16］Pang X, Liu J, Zhao J, et al. Homocysteine induces the expression of C-reactive protein via NMDAr-ROS-MAPK-NF-κB signal pathway in rat vascular smooth muscle cells［J］. Atherosclerosis, 2014, 236(1): 73-81.
［17］Paolicchi A, Minotti G, Tonarelli P, et al. Gamma-glutamyl transpeptidase-dependent iron reduction and LDL oxidation-a potential mechanism in atherosclerosis［J］. J Investig Med, 1999, 47(3): 151-160.
［18］Huipu X, Changmei L, Qinghai W, et al. Plaque image characteristics, hyperhomocysteinemia, and gene polymorphism of homocysteine metabolism-related enzyme (MTHFR C677T) in acute coronary syndrome［J］. Cell Biochem Biophys, 2013, 66(2): 403-407.
［19］Ussher JR, Natasha F, Wendy K, et al. Trimetazidine therapy prevents obesity-induced cardiomyopathy in mice［J］. Can J Cardiol, 2014, 30(8): 940-944.
［20］霍永佳. 氟伐他汀对高脂血症伴冠心病患者的临床疗效评价［J］. 中国临床药理学与治疗学, 2011, 16(2): 200-203.
［21］王珏, 乔青, 程茂良, 等. 银杏叶片对不稳定型心绞痛患者MPA、CD11b及MCP-1水平的影响［J］. 中国临床药理学与治疗学, 2017, 22(12): 1421-1425.

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[2]	YANG Chunyan, ZHANG Wen, WANG Peipei, PENG Jing, JIANG Jia, SONG Jing, LIU Jun, LI Yueran, YANG Kui, WANG Sheng, XU Zhenyu, LUAN Jiajie. Distribution of gene polymorphism in folate metabolism pathway and its effect on serumhomocysteine concentration [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2021, 26(11): 1259-1264.
[3]	XIE Xiangmei, HUANG Zhihong, LIU Xiaoju, XUE Bing, LAN Baozhu. Effects of atorvastatin and folic acid tablets on homocysteine and carotid atherosclerosis in patients with type H hypertension [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(4): 455-459.
[4]	YANG Liu, GUO Yi. Updating the evidence for the effect trimetazidine and shexiang baoxin pills on chronic heart failure: a Meta-analysis [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(6): 644-650.
[5]	ZHU Gang-yan, XU Hong-xin, TIAN Yi-hao, MA Hong-mei, TANG Shi-qi, WANG Fu-liang, WU Song-lin. Ameliorative effects of trimetazidine on bone marrow mesenchymal stem cells viability through Bcl-2 expression [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(7): 729-735.
[6]	FANG Xi, XUE Dan-ting, FANG Li, ZHANG Lu-yong. Endoplasmic reticulum stress and atherosclerosis [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(8): 947-951.
[7]	Acharya Dhan Kumar, DANG Yu-hua. Use of trimetazidine in ischemic heart disease [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(4): 385-391.
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[9]	DAI Zhen-Lin, DUAN Bao-Xiang, LI Jian-Chun. Clinical anti-ischemic effects of trimetazidine in the treatment of stable angina [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2001, 6(4): 343-345.