Comparison of responses induced by tracheal extubation between different doses of oxycodone after thyroidectomy

doi:10.12092/j.issn.1009-2501.2019.11.012

Abstract

Abstract:

AIM:To investigate the differences of the reaction induced by tracheal extubation between different doses of oxycodone after thyroidectomy. METHODS: After the unified anesthesia induction and maintenance regimen, eighty patients undergoing elective thyroidectomy were randomly divided into four groups receiving 0.05 mg/kg (group Q1), 0.1 mg/kg (group Q2), 0.15 mg/kg(group Q3) of intravenous oxycodone, or the same capacity of normal saline(group C) at 20-40 min before the end of surgery. MAP and HR were measured before anesthesia induction (T0), immediately after extubation(T1), at 5(T2) and 10 min(T3) after extubation. The recovery time of postoperative spontaneous breathe, awakening time, extubated time and the cough reflex caused by extubation were recorded. In addition, the OAA/S and VAS scores were marked at 5 min, 15 min, 30 min after entering the recovery room. RESULTS:Compared with T0, MAP and HR of group C and Q1 at T1, T2 increased significantly (P<0.05), while those of group Q2 and Q3 had no differences (P>0.05). Compared with group C, MAP and HR in group Q2, Q3 were lower (P<0.05) while those of group Q1 had no differences (P>0.05); the cough reflex of group Q2 and Q3 were lighter (P<0.05); the patients in group Q3 had the longer recovery time of postoperative spontaneous breathe and extubated time(P<0.05). Also, the VAS scores in PACU of three Q groups were lower than group C(P<0.05). CONCLUSION:Oxycodone administered at 20-40 min before the end of surgery can alleviate responses induced by extubation of the patients after thyroidectomy. 0.1 mg/kg of intravenous Oxycodone is the best dose for it can offer a better quality of recovery and postoperative analgesia with the fewer side effects.

Key words: oxycodone, thyroidectomy, responses of extubation

CLC Number:

LI Jiajia, SHENG Yi, HUANG Mengmeng, HAN Yuan, ZHU Chunchun, LIU Huacheng, LI Jun. Comparison of responses induced by tracheal extubation between different doses of oxycodone after thyroidectomy[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(11): 1287-1292.

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